There are a number of different factors that can contribute to vein disease. Age and sex both have a significant part to play. Age can cause wear and tear on the circulatory system that may lead to venous insufficiency. Therefore, patients are more likely to experience vein disease as they grow older. Women are more likely to have vein issues than men. It is theorized that hormonal changes that take place during puberty, pregnancy, and menopause put women at a higher risk.